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1,3-Dibromo-2-propanone → 7-chloro-2-[[2-bromo-1-(bromomethyl)ethylidene]hydrazino]-5-(o-fluorophenyl)-3H-1,4-benzodiazepine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 1,3-Dibromo-2-propanone | HCID 69952 | — |
| 反応物 | 7-chloro-2-hydrazino-5-(o-fluorophenyl)-3H-1,4-benzodiazepine | HCID 12390887 | — |
| 溶媒 | Tetrahydrofuran | HCID 8028 | — |
| 生成物 | 7-chloro-2-[[2-bromo-1-(bromomethyl)ethylidene]hydrazino]-5-(o-fluorophenyl)-3H-1,4-benzodiazepine | HCID 21431394 | — |
反応手順
In the manner given in Example 1, 7-chloro-2-hydrazino-5-(o-fluorophenyl)-3H-1,4-benzodiazepine in tetrahydrofuran can be treated with 1,3-dibromopropanone under nitrogen to give 7-chloro-2-[[2-bromo-1-(bromomethyl)ethylidene]hydrazino]-5-(o-fluorophenyl)-3H-1,4-benzodiazepine.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04028356 |
| 出典データセット | uspto-grants-1977_06 |
| ORD ID | ord-463a7a8ab7a2457c9ee7e5fcdcdbd439 |
| 出典メモ | uspto-grants-1977_06 |