3-Thiophenecarboxylic acid, 4-(aminosulfonyl)-, methyl ester → thieno[3,4-d]isothiazol-3(2H)-one 1,1-dioxide

HRID 436829ノート

反応式

HRID 436829 の反応式
[S:1]([C:5]1[C:6]([C:10]([O:12]C)=O)=[CH:7][S:8][CH:9]=1)(=[O:4])(=[O:3])[NH2:2]>C[O-].[Na+]>[O:12]=[C:10]1[C:6]2=[CH:7][S:8][CH:9]=[C:5]2[S:1](=[O:4])(=[O:3])[NH:2]1

参加物

3

反応物 1

HCID 30422843-Thiophenecarboxylic acid, 4-(aminosulfonyl)-, methyl ester

生成物 1

HCID 12593672thieno[3,4-d]isothiazol-3(2H)-one 1,1-dioxide

試薬・触媒・溶媒 1

HCID 10942334Sodium Methoxide溶媒

実験手順

31.6 g (0.143 mole) of methyl 4-sulfamoylthiophene-3-carboxylate (IX; R1 =H; R=CH3) is refluxed for 20 hours in 150 ml of 1N methanolic sodium methylate solution. The methanol is evaporated, the residue taken up in water, and the aqueous phase extracted with methylene chloride and acidified with concentrated hydrochloric acid; the product precipitates as crystals. It may be recrystallized from water or ethanol.

後処理

  1. customThe methanol is evaporated
  2. extractionthe aqueous phase extracted with methylene chloride
  3. customthe product precipitates as crystals
  4. customIt may be recrystallized from water or ethanol

出典と根拠

ORDレコード
ord-b62206d4007544b999d978bdea214581
出典データセット
uspto-grants-1977_06
特許番号
US04028373

反応ノート

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