Methyl 3-(aminosulfonyl)-2-thiophenecarboxylate → 2H,3H-1lambda6-thieno[2,3-d][1,2]thiazole-1,1,3-trione

HRID 436832

反応式

HRID 436832 の反応式
[S:1]([C:5]1[CH:9]=[CH:8][S:7][C:6]=1[C:10]([O:12]C)=O)(=[O:4])(=[O:3])[NH2:2]>C[O-].[Na+]>[O:12]=[C:10]1[C:6]2[S:7][CH:8]=[CH:9][C:5]=2[S:1](=[O:4])(=[O:3])[NH:2]1

参加物

3

反応物 1

HCID 101012Methyl 3-(aminosulfonyl)-2-thiophenecarboxylate

生成物 1

HCID 140865502H,3H-1lambda6-thieno[2,3-d][1,2]thiazole-1,1,3-trione

試薬・触媒・溶媒 1

HCID 10942334Sodium Methoxide溶媒

実験手順

32 g (0.145 mole) of methyl 3-sulfamoylthiophene-2-carboxylate (IX) in 145 ml of 1N methanolic sodium methylate solution is refluxed for 18 hours. The methanol is then evaporated off, the residue is taken up in water and a small amount of sodium bicarbonate, and the aqueous phase is extracted with methylene chloride and acidified with concentrated hydrochloric acid, whereupon the product precipitates as crystals which can be reprecipitated from water or ethanol.

後処理

  1. customThe methanol is then evaporated off
  2. extractiona small amount of sodium bicarbonate, and the aqueous phase is extracted with methylene chloride
  3. customprecipitates as crystals which
  4. customcan be reprecipitated from water or ethanol

出典と根拠

ORDレコード
ord-a1ab9e7cc2c4413ba4fb6912a1c95fbe
出典データセット
uspto-grants-1977_06
特許番号
US04028373

関連ノート

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