Diethylamine → N,N-diethyl-7,11-dimethyl-3-oxo-6,10-dodecadienamide

HRID 436876ノート

反応式

HRID 436876 の反応式
[CH3:1][C:2]([CH2:13][CH2:14][CH:15]=[C:16]([CH3:18])[CH3:17])=[CH:3][CH2:4][CH2:5][C:6](=[O:12])[CH2:7][C:8]([O:10]C)=O.[CH2:19]([NH:21][CH2:22][CH3:23])[CH3:20]>>[CH2:19]([N:21]([CH2:22][CH3:23])[C:8](=[O:10])[CH2:7][C:6](=[O:12])[CH2:5][CH2:4][CH:3]=[C:2]([CH3:1])[CH2:13][CH2:14][CH:15]=[C:16]([CH3:18])[CH3:17])[CH3:20]

参加物

3

反応物 2

HCID 8021DiethylamineHCID 53708905Methyl 3-oxo-7,11-dimethyl-dodeca-6,10-dienoate

生成物 1

HCID 53763853N,N-diethyl-7,11-dimethyl-3-oxo-6,10-dodecadienamide

実験手順

5.4 g of the product of Example 3 and 10.8ml of diethylamine were stirred in a closed auto clave at 110° C. for 70 hours and after cooling, the reaction mixture was recovered and evaporated under reduced pressure. The residue was chromatographed over silica and was eluted with a 1-1 ethyl etherpetroleum ether (b.p.= 40°-75° C.) mixture to obtain 3.6 g of N,N-diethyl-7,11-dimethyl-3-oxo-6,10-dodecadienamide in the form of an orange oil.

後処理

  1. temperatureafter cooling
  2. customthe reaction mixture was recovered
  3. customevaporated under reduced pressure
  4. customThe residue was chromatographed over silica
  5. washwas eluted with a 1-1 ethyl etherpetroleum ether (b.p.= 40°-75° C.) mixture

出典と根拠

ORDレコード
ord-ff084c6493d74762ba4e62702df6086c
出典データセット
uspto-grants-1977_06
特許番号
US04028386

反応ノート

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