Hydrochloric Acid → 10-Methoxy-6,10-dimethyl-5-undecene-2-one

HRID 436878ノート

反応式

HRID 436878 の反応式
C1CO[C:3]([CH2:5][CH2:6][CH:7]=[C:8]([CH3:17])[CH2:9][CH2:10][CH2:11][C:12]([O:15][CH3:16])([CH3:14])[CH3:13])([CH3:4])[O:2]1.Cl>CO.O>[CH3:16][O:15][C:12]([CH3:14])([CH3:13])[CH2:11][CH2:10][CH2:9][C:8]([CH3:17])=[CH:7][CH2:6][CH2:5][C:3](=[O:2])[CH3:4]

参加物

5

反応物 2

HCID 313Hydrochloric AcidHCID 77886384HCID 77886384、化合物

生成物 1

HCID 5396652510-Methoxy-6,10-dimethyl-5-undecene-2-one収率 97.7%

試薬・触媒・溶媒 2

HCID 887Methanol溶媒HCID 962Water溶媒

実験手順

This and the next reaction could be effected with the E and Z isomers or mixtures thereof. A solution of 1.1 g of 2,2-ethylenedioxy-10-methoxy-6,10-dimethyl-5-undecene in 22 ml of methanol containing 11 ml of 0.5N aqueous hydrochloric acid was stirred for 20 hours at room temperature and was then diluted with water and extracted with petroleum ether (b.p.= 40°-75° C.). The extracts were washed with an aqueous sodium bicarbonate solution, then with water and evaporated to dryness to obtain 900 mg of 10-methoxy-6,10-dimethyl-5-undecene-2-one in the form of a colorless oil which was used as is for the next step.

後処理

  1. customThis and the next reaction
  2. extractionextracted with petroleum ether (b.p.= 40°-75° C.)
  3. washThe extracts were washed with an aqueous sodium bicarbonate solution
  4. customwith water and evaporated to dryness

出典と根拠

ORDレコード
ord-ffc1eb2e07c54bd5b522fd7ebf07e5e6
出典データセット
uspto-grants-1977_06
特許番号
US04028386

反応ノート

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