Water → Cyclobutyl(4-methylphenyl)methanone

HRID 436926ノート

反応式

HRID 436926 の反応式
[CH:1]1([C:5](Cl)=[O:6])[CH2:4][CH2:3][CH2:2]1.[Cl-].[Al+3].[Cl-].[Cl-].O.[C:13]1([CH3:19])[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1>>[C:13]1([CH3:19])[CH:18]=[CH:17][C:16]([C:5]([CH:1]2[CH2:4][CH2:3][CH2:2]2)=[O:6])=[CH:15][CH:14]=1

参加物

5

反応物 4

HCID 962WaterHCID 1140Toluene2 回HCID 78705Cyclobutanecarbonyl chlorideHCID 6451240Aluminum(III) Chloride

生成物 1

HCID 316820Cyclobutyl(4-methylphenyl)methanone

実験手順

Cyclobutylcarbonyl chloride (23.8 g.) in dry toluene (25 ml) was added dropwise during 1 hour to a stirred suspension of anhydrous aluminium chloride (29.4 g) in dry toluene (150 ml). After stirring a further 20 minutes, the mixture was poured into iced water (1 l) and the organic layer was separated, washed with water, dried over magnesium sulphate, filtered and evaporated. The residue was distilled under reduced pressure and the fraction b.p. 79-80°/0.03 mm was collected. On standing the product solidified and the solid had m.p. 32°-34°.

後処理

  1. customthe organic layer was separated
  2. washwashed with water
  3. dry with materialdried over magnesium sulphate
  4. filtrationfiltered
  5. customevaporated
  6. distillationThe residue was distilled under reduced pressure
  7. customthe fraction b.p. 79-80°/0.03 mm was collected

出典と根拠

ORDレコード
ord-6f813a29c7da4115a3f02b2b9428c00e
出典データセット
uspto-grants-1977_06
特許番号
US04028404

反応ノート

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