N-Methylethylamine → 3-(N-methyl-N-ethylamino)-1,1-diphenyl-propan-2-ol

HRID 436942ノート

反応式

HRID 436942 の反応式
[CH3:1][NH:2][CH2:3][CH3:4].[C:5]1([CH:11]([C:16]2[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=2)[CH:12]([OH:15])[CH2:13]Br)[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1>C(O)C>[CH3:1][N:2]([CH2:13][CH:12]([OH:15])[CH:11]([C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1)[C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1)[CH2:3][CH3:4]

参加物

4

反応物 2

HCID 12219N-MethylethylamineHCID 125490671,1-Diphenyl-3-bromopropan-2-ol

生成物 1

HCID 125490683-(N-methyl-N-ethylamino)-1,1-diphenyl-propan-2-ol

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

Excess N methyl-N-ethylamine was added to a solution of 1,1 -diphenyl-3-bromo-propan-2-ol (2 g.) in ethanol. After 60 hours the solution was evaporated and the residue was evaporated and the residue dissolved in dilute hydrochloric acid and ether. Basification of the acid extract and subsequent isolation through ether in the usual manner gave 3-(N-methyl-N-ethylamino)-1,1 -diphenyl-propan-2-ol isolated as the hydrochloride (1 25 g., 60%), m.p. 159° - 161°.

後処理

  1. customAfter 60 hours the solution was evaporated
  2. customthe residue was evaporated
  3. dissolutionthe residue dissolved in dilute hydrochloric acid
  4. extractionBasification of the acid extract

出典と根拠

ORDレコード
ord-dca66422e497478faf6ec7f2f1bf388b
出典データセット
uspto-grants-1977_06
特許番号
US04028415

反応ノート

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