Dimethylamine → 3-Dimethylamino-1,1-diphenyl-propan-2-ol

HRID 436945ノート

反応式

HRID 436945 の反応式
[C:1]1([CH:7]([C:12]2[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=2)[CH:8]([OH:11])[CH2:9]Br)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[CH3:18][NH:19][CH3:20]>C(O)C>[CH3:18][N:19]([CH3:20])[CH2:9][CH:8]([OH:11])[CH:7]([C:12]1[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1)[C:1]1[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

参加物

4

反応物 2

HCID 674DimethylamineHCID 125490671,1-Diphenyl-3-bromopropan-2-ol

生成物 1

HCID 125491223-Dimethylamino-1,1-diphenyl-propan-2-ol収率 75%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

1,1-Diphenyl-3-bromopropan-2-ol (500 mg.) prepared as described in Example 20 was treated with excess dimethylamine in ethanol and the solution allowed to stand overnight. Solvent was removed by evaporation and the residue dissolved in dilute hydrochloric acid and ether. Basification of the acid extract and isolation through ether in the usual manner gave 3-dimethylamino-1,1-diphenyl-propan-2-ol (330 mg., 75%), m.p. 72° - 73°.

後処理

  1. customSolvent was removed by evaporation
  2. dissolutionthe residue dissolved in dilute hydrochloric acid
  3. extractionBasification of the acid extract

出典と根拠

ORDレコード
ord-1dfed4f348254ebc9e20da6f22ffbfc0
出典データセット
uspto-grants-1977_06
特許番号
US04028415

反応ノート

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