Hydrochloric Acid → HCID 70633642、化合物

HRID 436952ノート

反応式

HRID 436952 の反応式
[Cl:1]C1C=C(Cl)C(Cl)=CC=1OC(=O)[C@H](CC1C=CC=CC=1)NC(OC(C)(C)C)=O.C(OC(=O)[C@H](CCSC)N)C1C=CC=CC=1.[CH2:45]([O:52][C:53](=[O:78])[C@H:54]([CH2:74][CH2:75][S:76][CH3:77])[NH:55][C:56](=[O:73])[C@H:57]([CH2:66][C:67]1[CH:72]=[CH:71][CH:70]=[CH:69][CH:68]=1)[NH:58]C(OC(C)(C)C)=O)[C:46]1[CH:51]=[CH:50][CH:49]=[CH:48][CH:47]=1.Cl>O1CCOCC1.C(Cl)Cl>[ClH:1].[CH2:45]([O:52][C:53](=[O:78])[C@H:54]([CH2:74][CH2:75][S:76][CH3:77])[NH:55][C:56](=[O:73])[C@H:57]([CH2:66][C:67]1[CH:68]=[CH:69][CH:70]=[CH:71][CH:72]=1)[NH2:58])[C:46]1[CH:51]=[CH:50][CH:49]=[CH:48][CH:47]=1

参加物

7

反応物 4

HCID 313Hydrochloric AcidHCID 11673142HCID 11673142、化合物HCID 13306570N-t-butoxycarbonyl-L-phenylalanine 2,4,5-trichlorophenyl esterHCID 53827275HCID 53827275、化合物

生成物 1

HCID 70633642HCID 70633642、化合物

試薬・触媒・溶媒 2

HCID 6344Dichloromethane溶媒HCID 312751,4-Dioxane溶媒2 回

実験手順

A solution of 21.2 parts N-t-butoxycarbonyl-L-phenylalanine 2,4,5-trichlorophenyl ester and 12.7 parts L-methionine benzyl ester in 200 parts methylene chloride is stirred overnight at room temperature. Completion of the reaction is determined by thin layer chromatography. The solvent is then stripped under reduced pressure and the crude residue subjected to low pressure column chromatography on silica gel. The resulting product, N-t-butoxycarbonyl-L-phenylalanyl-L-methionine benzyl ester, is dissolved in 50 parts dioxane and stirred with a 10 fold excess of 2 N HCl in dioxane for 10 minutes. The solvent is removed by evaporation under reduced pressure. The solid residue, after trituration with ethyl ether, affords pure L-phenylalanyl-L-methionine benzyl ester hydrochloride. This compound is represented by the following formula

後処理

  1. customThe solvent is removed by evaporation under reduced pressure

出典と根拠

ORDレコード
ord-13666bc650ac4756b6681b33277d8db6
出典データセット
uspto-grants-1977_06
特許番号
US04028319

反応ノート

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