Potassium Carbonate → 2-(Tert-butoxy)acetic acid

HRID 4371

反応式

HRID 4371 の反応式
C(=O)([O-])[O-].[K+].[K+].[C:7]([O:11][CH2:12][C:13]([O:15]CCCC)=[O:14])([CH3:10])([CH3:9])[CH3:8]>CO.O>[C:7]([O:11][CH2:12][C:13]([OH:15])=[O:14])([CH3:10])([CH3:9])[CH3:8]

参加物

4

反応物 2

HCID 11430Potassium CarbonateHCID 14050415Butyl tert-butoxyacetate

生成物 1

HCID 27609982-(Tert-butoxy)acetic acid

試薬・触媒・溶媒 1

HCID 22242641Methanol--water (1/1)溶媒

反応条件

温度
0 °C

実験手順

To 100 ml of a 50:50 (v/v) methanol/water solution containing 14.35 g of potassium carbonate, was added n-butyl 2-tert-butoxyacetate (6.50 g, 0.0346 mol). The mixture was heated at reflux for 17 hours and the volatiles removed on a flash evaporator. The remaining solution was cooled to approximately 0° C. and acidified to pH 3-4 with cold 50% aqueous hydrogen chloride. The product was extracted with ether, the ether extract washed with brine and dried over magnesium sulfate, then concentrated in vacuo to give the title compound as a yellow liquid.

後処理

  1. temperatureThe mixture was heated
  2. temperatureat reflux for 17 hours
  3. customthe volatiles removed on a flash evaporator
  4. extractionThe product was extracted with ether
  5. extractionthe ether extract
  6. washwashed with brine
  7. dry with materialdried over magnesium sulfate
  8. concentrationconcentrated in vacuo

出典と根拠

ORDレコード
ord-683c16909174462faf1b49adbea715f3
出典データセット
uspto-grants-1988_02
特許番号
US04725620

関連ノート

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