Hydroxyacetonitrile → Cyanomethyl thiophene-2-sulfonate
反応式
[C:1](#[N:4])[CH2:2][OH:3].[S:5]1[CH:9]=[CH:8][CH:7]=[C:6]1[S:10](Cl)(=[O:12])=[O:11]>C(OCC)C>[S:5]1[CH:9]=[CH:8][CH:7]=[C:6]1[S:10]([O:3][CH2:2][C:1]#[N:4])(=[O:12])=[O:11]参加物
4
実験手順
Method of preparation: Glycolonitrile is reacted with 2-thiophenesulfonyl chloride using the procedure as described in the previous example, with 2 hours of reaction at 0° C., followed by three hours at room temperature. The reaction mixture separates into two layers; the bottom dark layer is isolated and dissolved in diethyl ether, the solution washed with weak caustic solution and cold water, and the solvent is stripped off under reduced pressure to give the product (in 79% conversion), a green oily liquid, nD24.5 1.535.
後処理
- customMethod of preparation
- customas described in the previous example, with 2 hours of reaction at 0° C.
- customthe bottom dark layer is isolated
- washthe solution washed with weak caustic solution and cold water
- customto give the product (in 79% conversion)
出典と根拠
- ORDレコード
- ord-022c477181ea4de59e8ceadaf7dfd2ed
- 出典データセット
- uspto-grants-1977_06
- 特許番号
- US04029809
反応ノート
読み込み中…