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2,5-Dichlorobenzoic acid → 5-Chloro-2-[2-methyl-3-(trifluoromethyl)anilino]benzoic acid
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2,5-Dichlorobenzoic acid | HCID 5784 | — |
| 反応物 | 1-Pentanol | HCID 6276 | — |
| 反応物 | Sodium Hydroxide | HCID 14798 | — |
| 反応物 | Trifluoromethyl toluidine | HCID 2735932 | — |
| 触媒 | Copper | HCID 23978 | — |
| 生成物 | 5-Chloro-2-[2-methyl-3-(trifluoromethyl)anilino]benzoic acid | HCID 45117703 | — |
反応手順
To a solution of 25 g. of 2,5-dichlorobenzoic acid in 125 ml. of n-pentyl alcohol add 4.8 g. of sodium hydroxide pellets, 25 g. of 2-methyl-3-trifluoromethylaniline and 2 g. of copper powder. With constant stirring, reflux the reaction mixture for 18 hours. Concentrate the mixture to one half volume and dilute with water and ether. Acidify the aqueous layer to yield the product which is recrystallized from methanol, m.p. 220°-222° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04029815 |
| 出典データセット | uspto-grants-1977_06 |
| ORD ID | ord-4d4f4c4afad6436984261a6ffd258e11 |
| 出典メモ | uspto-grants-1977_06 |