Potassium Carbonate → HCID 21430607、化合物

HRID 437221ノート

反応式

HRID 437221 の反応式
Br[CH2:2][CH2:3][C:4]1[C:12]2[C:7](=[CH:8][CH:9]=[CH:10][CH:11]=2)[CH2:6][CH:5]=1.[C:13]([NH:21][CH:22]1[CH2:27][CH2:26][NH:25][CH2:24][CH2:23]1)(=[O:20])[C:14]1[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=1.C(=O)([O-])[O-].[K+].[K+]>C(O)(C)C>[CH2:6]1[C:7]2[C:12](=[CH:11][CH:10]=[CH:9][CH:8]=2)[C:4]([CH2:3][CH2:2][N:25]2[CH2:26][CH2:27][CH:22]([NH:21][C:13](=[O:20])[C:14]3[CH:19]=[CH:18][CH:17]=[CH:16][CH:15]=3)[CH2:23][CH2:24]2)=[CH:5]1

参加物

5

反応物 3

HCID 11430Potassium CarbonateHCID 118120N-4-PiperidylbenzamideHCID 121780961-bromo-2-(3-indenyl)ethane

生成物 1

HCID 21430607HCID 21430607、化合物

試薬・触媒・溶媒 1

HCID 3776Isopropanol溶媒

実験手順

3-(2-Bromoethyl)indene (1.12 g.), 4-benzamidopiperidine (1.02 g.) and potassium carbonate (1.38 g.) were heated under reflux in isopropanol (25 ml.) for 24 hours. The mixture was filtered and the filtrate was evaporated. Trituration of the residue with ether gave a solid which was recrystallised twice from aqueous ethanol to provide the title compound, m.p. 148°-149° C. (Found: C, 79.7; H, 7.6; N, 8.0. C23H26N2O requires C, 79.7; H, 7.6; N, 8.1%).

後処理

  1. filtrationThe mixture was filtered
  2. customthe filtrate was evaporated
  3. customTrituration of the residue with ether gave a solid which
  4. customwas recrystallised twice from aqueous ethanol

出典と根拠

ORDレコード
ord-47494834c1144272b3ab85191e977b1c
出典データセット
uspto-grants-1977_06
特許番号
US04029801

反応ノート

読み込み中…