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Potassium Carbonate → 1-[3-(1-Naphthoxy)-2-hydroxyprop-1-yl]-4-benzamidopiperidine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | 1-Chloro-3-(1-naphthyloxy)-2-propanol | HCID 89276 | — |
| 反応物 | N-4-Piperidylbenzamide | HCID 118120 | — |
| 溶媒 | Isopropanol | HCID 3776 | — |
| 生成物 | 1-[3-(1-Naphthoxy)-2-hydroxyprop-1-yl]-4-benzamidopiperidine | HCID 21430647 | — |
反応手順
3-(α-Naphthoxy)-1-chloropropan-2-ol (1.18 g.) was refluxed for 16 hours in isopropyl alcohol (100 ml.) with 4-benzamidopiperidine (1.032 g.) and anhydrous potassium carbonate (1.037 g.). The mixture was filtered hot, cooled and evaporated to dryness. The gum so obtained gave the title compound as a solid on triturating in ether, m.p. 139°-141° C. (Found: C, 74.1; H, 7.1; N, 6.9. C25H28N2O3 requires C, 74.2; H, 7.0; N, 6.9%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04029801 |
| 出典データセット | uspto-grants-1977_06 |
| ORD ID | ord-8fb03f6ffe34446b84c56e7af70e3b1a |
| 出典メモ | uspto-grants-1977_06 |