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2-Naphthaleneethanol → 4-Benzamido-1-[2-(2-naphthyl)ethyl]piperidine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 2-Naphthaleneethanol | HCID 73877 | — |
| 反応物 | N-4-Piperidylbenzamide | HCID 118120 | — |
| 触媒 | Nickel | HCID 935 | — |
| 溶媒 | O-Xylene | HCID 7237 | — |
| 生成物 | 4-Benzamido-1-[2-(2-naphthyl)ethyl]piperidine | HCID 21430613 | — |
反応手順
2-(2-Naphthyl)ethanol (3.44 g., 0.02 mole), 4-benzamidopiperidine (4.08 g., 0.02 mole) and Raney Nickel (W7 ca. 5 g.) were suspended in xylene (200 ml.) and the stirred mixture boiled under reflux for 16 hours. Liberated water was removed by means of a Dean and Stark apparatus. The mixture was filtered hot and evaporated to ca. 100 ml. The resulting yellow solution was stored until crystallisation was complete. The title compound was obtained as off-white needles (3.30 g.), m.p. 189°-191° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04029801 |
| 出典データセット | uspto-grants-1977_06 |
| ORD ID | ord-f0ae86a5d7d94fe7a08083e5cbbad43a |
| 出典メモ | uspto-grants-1977_06 |