Diethyl Ether → 2-(2-Aminophenyl)propan-2-ol
反応式
[NH2:1][C:2]1[CH:11]=[CH:10][CH:9]=[CH:8][C:3]=1C(OC)=O.[CH3:12][Mg]I.C([O:17][CH2:18][CH3:19])C>[Cl-].[NH4+]>[CH3:12][C:18]([OH:17])([CH3:19])[C:3]1[CH:8]=[CH:9][CH:10]=[CH:11][C:2]=1[NH2:1]参加物
5
実験手順
A 30.2-g (0.2 mol) sample of methyl 2-aminobenzoate in 150 ml diethyl ether was added dropwise to a solution of methyl magnesium iodide (prepared from 19.4 g of Mg and 127.8 g of methyl iodide) in 150 ml diethyl ether. The reaction mixture was then heated under reflux for 1 hour, cooled, and diluted with 200 ml of saturated aqueous ammonium chloride solution. The resulting aqueous mixture was extracted with ether. The ether extracts were dried over magnesium sulfate and evaporated to give 19.1 g of α,α-dimethyl-2-aminobenzyl alcohol.
後処理
- temperatureThe reaction mixture was then heated
- temperatureunder reflux for 1 hour
- temperaturecooled
- extractionThe resulting aqueous mixture was extracted with ether
- dry with materialThe ether extracts were dried over magnesium sulfate
- customevaporated
出典と根拠
- ORDレコード
- ord-b239c5ceacbc4e17a689c95c775bb75c
- 出典データセット
- uspto-grants-1977_06
- 特許番号
- US04030906
反応ノート
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