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HRID 437318作成日：2026年10月26日
Trichlorofluoromethane → 5-Fluoro-2-methyl-1-((4-(methylsulfinyl)phenyl)methylene)-1H-indene-3-acetic acid
https://huagongshe.com/reaction/437318
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|
| 反応物 | Trichlorofluoromethane | HCID 6389 | — |
| 反応物 | Hypofluorous acid, trifluoromethyl ester | HCID 78989 | — |
| 反応物 | HCID 54462256 | HCID 54462256 | — |
| 生成物 | 5-Fluoro-2-methyl-1-((4-(methylsulfinyl)phenyl)methylene)-1H-indene-3-acetic acid | HCID 5352 | — |
反応手順
2-Methyl-1-(p-methylsulfinylbenzylidene)inden-3-acetic acid (2.25 g.) dissolved in 80 ml. of fluorotrichloromethane was ultraviolet irradiated and stirred at -15° C. for 80 min.; meanwhile 1.2 g. of fluoroxytrifluoromethane was passed in. The residue obtained after evaporation of the solvent was subjected to chromatography on a silica gel column, to give 5-fluoro-2-methyl-1-(p-methylsulfinylbenzylidene)inden-3-acetic acid, m.p. 188°-189° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 特許番号 | US04030994 |
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| 出典データセット | uspto-grants-1977_06 |
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| ORD ID | ord-66baa80bd4b84666895fb2918415098e |
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| 出典メモ | uspto-grants-1977_06 |
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