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Dicyclohexylcarbodiimide → Nalpha-t-Butoxycarbonyl-D-alanyl-D-leucine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Dicyclohexylcarbodiimide | HCID 10868 | — |
| 反応物 | tert-Butoxycarbonyl-D-leucine | HCID 637604 | — |
| 反応物 | BOC-D-alanine | HCID 637606 | — |
| 溶媒 | Chloroform | HCID 6212 | — |
| 生成物 | Nalpha-t-Butoxycarbonyl-D-alanyl-D-leucine | HCID 53724831 | — |
反応手順
Nα-t-Butoxycarbonyl-D-leucine resin (53 g., 42.9 mmol) is deprotected as in part (b), and Nα-t-butoxycarbonyl-D-alanine (8.5 g., 45 mmol) is added followed by the addition of dicyclohexylcarbodiimide, 9.3 g., 45 mmol in chloroform, after 15 to 30 minutes, followed by agitation for 18 hours. The product is separated by filtration and washed three times with dichloromethane, 250 ml., and dried.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04031071 |
| 出典データセット | uspto-grants-1977_06 |
| ORD ID | ord-a9f21c9effb14dcaa24c62b65729a608 |
| 出典メモ | uspto-grants-1977_06 |