Dicyclohexylcarbodiimide → Nalpha-t-Butoxycarbonyl-D-alanyl-D-leucine

HRID 437331

反応式

HRID 437331 の反応式
C(OC([NH:8][C@@H:9]([C:14]([OH:16])=[O:15])[CH2:10][CH:11]([CH3:13])[CH3:12])=O)(C)(C)C.[C:17]([O:21][C:22]([NH:24][C@@H:25]([C:27]([OH:29])=O)[CH3:26])=[O:23])([CH3:20])([CH3:19])[CH3:18].C1(N=C=NC2CCCCC2)CCCCC1>C(Cl)(Cl)Cl>[C:17]([O:21][C:22]([NH:24][C@@H:25]([C:27]([NH:8][C@@H:9]([C:14]([OH:16])=[O:15])[CH2:10][CH:11]([CH3:13])[CH3:12])=[O:29])[CH3:26])=[O:23])([CH3:18])([CH3:19])[CH3:20]

参加物

5

反応物 3

HCID 10868DicyclohexylcarbodiimideHCID 637604tert-Butoxycarbonyl-D-leucineHCID 637606BOC-D-alanine

生成物 1

HCID 53724831Nalpha-t-Butoxycarbonyl-D-alanyl-D-leucine

試薬・触媒・溶媒 1

HCID 6212Chloroform溶媒

実験手順

Nα-t-Butoxycarbonyl-D-leucine resin (53 g., 42.9 mmol) is deprotected as in part (b), and Nα-t-butoxycarbonyl-D-alanine (8.5 g., 45 mmol) is added followed by the addition of dicyclohexylcarbodiimide, 9.3 g., 45 mmol in chloroform, after 15 to 30 minutes, followed by agitation for 18 hours. The product is separated by filtration and washed three times with dichloromethane, 250 ml., and dried.

後処理

  1. additionis added
  2. customThe product is separated by filtration
  3. washwashed three times with dichloromethane, 250 ml
  4. custom, and dried

出典と根拠

ORDレコード
ord-a9f21c9effb14dcaa24c62b65729a608
出典データセット
uspto-grants-1977_06
特許番号
US04031071

関連ノート

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