4-(Chloromethyl)phenylacetic acid → Phenylacetic Acid

HRID 437353ノート

反応式

HRID 437353 の反応式
ClC[C:3]1[CH:8]=[CH:7][C:6]([CH2:9][C:10]([OH:12])=[O:11])=[CH:5][CH:4]=1.O1CCN(NC(=S)[S-])CC1>CO>[C:6]1([CH2:9][C:10]([OH:12])=[O:11])[CH:7]=[CH:8][CH:3]=[CH:4][CH:5]=1

参加物

4

反応物 2

HCID 103134194-(Chloromethyl)phenylacetic acidHCID 21792278Morpholinodithiocarbamate

生成物 1

HCID 999Phenylacetic Acid

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

A solution of 1.85 g (0.01 mole) of 4-chloromethylphenyl acetic acid and 6.25 g (0.025 mole) of freshly prepared morpholinodithiocarbamate salt in 250 ml of methanol was stirred under nitrogen for 20 hours at room temperature. The solvent was evaporated, water was added and the solution was acidified to pH 1 using aqueous 10% hydrochloric acid then extracted with ethylacetate, dried over anhydrous magnesium sulfate and evaporated. The residue was recrystallized from ethylacetate to give p-morpholinodithiocarbamatemethyl)phenylacetic acid. M.P. 163° C.

後処理

  1. customThe solvent was evaporated
  2. additionwater was added
  3. extractionthen extracted with ethylacetate
  4. dry with materialdried over anhydrous magnesium sulfate
  5. customevaporated
  6. customThe residue was recrystallized from ethylacetate

出典と根拠

ORDレコード
ord-e96337b4aaed454dba47a3b07ac2578c
出典データセット
uspto-grants-1977_06
特許番号
US04031083

反応ノート

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