HCID 54682948、化合物 → 4-Hydroxy-5,6,7,8-tetrahydroquinolin-2(1H)-one
反応式
C([C:6]1[C:7](=[O:17])[NH:8][C:9]2[CH2:10][CH2:11][CH2:12][CH2:13][C:14]=2[C:15]=1[OH:16])(OCC)=O>Cl>[OH:16][C:15]1[C:14]2[CH2:13][CH2:12][CH2:11][CH2:10][C:9]=2[NH:8][C:7](=[O:17])[CH:6]=1参加物
3
実験手順
A suspension of 3-carboethoxy-4-hydroxy-5,6,7,8-tetrahydro-carbostyril (19.4g; 0.082 mole) in 2N hydrochloric acid (200 ml) was refluxed 30 hrs. and the clear solution evaporated to dryness. Water was added and the solution brought to pH 4.0 with dilute sodium hydroxide solution. The precipitated white product was filtered off, washed well with water and recrystallised from glacial acetic acid, m.p. >330° C.
後処理
- temperaturewas refluxed 30 hrs
- customand the clear solution evaporated to dryness
- additionWater was added
- filtrationThe precipitated white product was filtered off
- washwashed well with water
- customrecrystallised from glacial acetic acid, m.p. >330° C.
出典と根拠
- ORDレコード
- ord-ab229d0829e7406284b198965c6f9a3c
- 出典データセット
- uspto-grants-1977_06
- 特許番号
- US04031099
反応ノート
読み込み中…