化工社化工社 化学情報印刷レポート · 研究参考用
Sodium Iodide → HCID 14810575、化合物
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Sodium Iodide | HCID 5238 | — |
| 反応物 | Butanoic acid, 4-chloro-, methyl ester | HCID 76612 | — |
| 反応物 | rel-(2R,6S)-2,6-Dimethylpiperidine | HCID 641768 | — |
| 溶媒 | O-Xylene | HCID 7237 | — |
| 生成物 | HCID 14810575 | HCID 14810575 | — |
反応手順
A mixture of 273 g. of methyl 4-chlorobutyrate, 460 g. of cis-2,6-dimethylpiperidine, 10 g. of sodium iodide and 300 ml. of xylene is stirred and heated at reflux for 44 hours, then cooled and filtered. The filter cake is washed with xylene and the combined filtrate and washings are evaporated at reduced pressure to give cis-2,6-dimethyl-1-piperidinebutyric acid, methyl ester which is purified by distillation; b.p. 79°-81° C./0.5 mm.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04031101 |
| 出典データセット | uspto-grants-1977_06 |
| ORD ID | ord-d2f3b55717314692bbbb371b3e3261ff |
| 出典メモ | uspto-grants-1977_06 |