3-Bromo-1-propanol → HCID 13239624、化合物

HRID 437386

反応式

HRID 437386 の反応式
[CH3:1][C@H:2]1[CH2:7][CH2:6][CH2:5][C@@H:4]([CH3:8])[NH:3]1.Br[CH2:10][CH2:11][CH2:12][OH:13]>C1(C)C(C)=CC=CC=1>[CH3:1][C@H:2]1[CH2:7][CH2:6][CH2:5][C@@H:4]([CH3:8])[N:3]1[CH2:10][CH2:11][CH2:12][OH:13]

参加物

4

反応物 2

HCID 123083-Bromo-1-propanolHCID 641768rel-(2R,6S)-2,6-Dimethylpiperidine

生成物 1

HCID 13239624HCID 13239624、化合物

試薬・触媒・溶媒 1

HCID 7237O-Xylene溶媒

実験手順

A stirred solution of 460 g. of cis-2,6-dimethylpiperidine in 300 ml. of xylene is treated with 278 g. of 3-bromopropanol over a period of 15 minutes. The mixture is stirred and heated at reflux for 2 hours, then allowed to cool while stirring for 16 hours. The mixture is filtered and the filtrate evaporated at reduced pressure. The residue is distilled at reduced pressure to give cis-2,6-dimethyl-1-piperidinepropanol; b.p. 147°-149° C./25 mm.

後処理

  1. temperatureheated
  2. temperatureat reflux for 2 hours
  3. temperatureto cool
  4. stirringwhile stirring for 16 hours
  5. filtrationThe mixture is filtered
  6. customthe filtrate evaporated at reduced pressure
  7. distillationThe residue is distilled at reduced pressure

出典と根拠

ORDレコード
ord-c4a51d1f1ffb49698711afb4b5e819b1
出典データセット
uspto-grants-1977_06
特許番号
US04031101

関連ノート

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