Hydrochloric Acid → Pirbuterol Hydrochloride

HRID 437395ノート

反応式

HRID 437395 の反応式
[ClH:1].CC1(C)[O:8][C:7]2[CH:9]=[CH:10][C:11]([CH:13]([OH:20])[CH2:14][NH:15][C:16]([CH3:19])([CH3:18])[CH3:17])=[N:12][C:6]=2[CH2:5][O:4]1>CO>[ClH:1].[ClH:1].[OH:4][CH2:5][C:6]1[C:7]([OH:8])=[CH:9][CH:10]=[C:11]([CH:13]([OH:20])[CH2:14][NH:15][C:16]([CH3:18])([CH3:17])[CH3:19])[N:12]=1

参加物

4

反応物 2

HCID 313Hydrochloric AcidHCID 21428405α-[[(1,1-Dimethylethyl)amino]methyl]-2,2-dimethyl-4H-1,3-dioxino[5,4-b]pyridine-6-methanol

生成物 1

HCID 68658Pirbuterol Hydrochloride

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

To 10 ml. of methanol and 10 ml. of 10% hydrochloric acid is added 227 mg. of 2,2-dimethyl-6-(1-hydroxy-2-t-butylaminoethyl)-4H-pyrido[3,2-d]-1,3-dioxin, and the resulting reaction mixture allowed to stir at room temperature for 1.5 hrs. Removal of the solvents under vacuum at 70° C. provides 230 mg. of the desired product, which is identical by nuclear magnetic resonance spectroscopy to the product in U.S. Pat. No. 3,700,681.

後処理

  1. customRemoval of the solvents under vacuum at 70° C.
  2. customprovides 230 mg

出典と根拠

ORDレコード
ord-698ce46ad0944fa2883190a1369c92ab
出典データセット
uspto-grants-1977_06
特許番号
US04031108

反応ノート

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