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Bicarbonate Ion → Fluoromidine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Bicarbonate Ion | HCID 769 | — |
| 反応物 | Diethyl Ether | HCID 3283 | — |
| 反応物 | Sodium Iodide | HCID 5238 | — |
| 反応物 | 1-(METHYLSULFONYLOXY)-6-CHLORO-2-(TRIFLUOROMETHYL)-1H-IMIDAZO(4,5-b)PYRIDINE | HCID 20359924 | — |
| 溶媒 | Acetone | HCID 180 | — |
| 生成物 | Fluoromidine | HCID 911208 | 73% |
反応手順
1-(Methylsulfonyloxy)-6-chloro-2-(trifluoromethyl)-1H-imidazo [4,5-b] pyridine (20 milligrams) in 0.5 milliliter of acetone was treated with 0.1 gram of sodium iodide in 0.5 milliliter of acetone. The reaction mixture was shaken with ether and bicarbonate solution. The ether portion was dried over magnesium sulfate and evaporated, yielding 10 milligrams (about 73 percent) of 6-chloro-2-(trifluoromethyl)-1H-imidazo [4,5-b] pyridine.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04031107 |
| 出典データセット | uspto-grants-1977_06 |
| ORD ID | ord-fde4c1ece5ef45c68a2011d043d95a1d |
| 出典メモ | uspto-grants-1977_06 |