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Iodoethane → 5-Chloro-2-ethoxybenzamide
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Iodoethane | HCID 6340 | — |
| 反応物 | Potassium Carbonate | HCID 11430 | — |
| 反応物 | 5-Chloro-2-hydroxybenzamide | HCID 348094 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | 5-Chloro-2-ethoxybenzamide | HCID 20360293 | 36.6% |
反応手順
A mixture of 5-chlorosalicylamide (16.0 g., 0.093 mole), iodoethane (31.8 g., 0.204 mole), and potassium carbonate (13.1 g., 0.095 mole) in ethanol (225 ml.) was heated under reflux for 20 hours. The hot mixture was filtered. The filtrate was reduced to dryness. The residue was triturated with water. The mixture was filtered and the collected solid recrystallized from acetonitrile to give 5-chloro-2-ethoxybenzamide (6.8 g., 36.6%) m.p. 136°-139°.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04031093 |
| 出典データセット | uspto-grants-1977_06 |
| ORD ID | ord-a41ab30757f346f09213a2bfca4b3c19 |
| 出典メモ | uspto-grants-1977_06 |