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Water → 1-(1H-Imidazol-1-ylcarbonyl)-L-proline methyl ester
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Water | HCID 962 | — |
| 反応物 | Triethylamine | HCID 8471 | — |
| 反応物 | 1,1'-Carbonyldiimidazole | HCID 68263 | — |
| 反応物 | methyl L-prolinate hydrochloride | HCID 2733200 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | 1-(1H-Imidazol-1-ylcarbonyl)-L-proline methyl ester | HCID 67548889 | 100% |
反応手順
L-proline methyl ester hydrochloride (0.300 g, 1.81 mmol) was dissolved in dichloromethane (5 ml). Triethylamine (0.202 g, 1.99 mmol) and 1,1′-carbonylbis-1H-imidazole (0.352 g, 2.17 mmol) were added, and the mixture was stirred at room temperature for five days. Water was added to the reaction solution, followed by extraction with dichloromethane. Then, the organic layer was washed with brine and dried over anhydrous sodium sulfate. Following concentration under reduced pressure, 0.404g of the title compound was obtained as a colorless oily substance (100%).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08536197B2 |
| 出典データセット | uspto-grants-2013_09 |
| ORD ID | ord-86d9760c76fb49ea90d9def8ad4650fb |
| 出典メモ | uspto-grants-2013_09 |