Water → 1-(1H-Imidazol-1-ylcarbonyl)-L-proline methyl ester

HRID 43745

反応式

HRID 43745 の反応式
Cl.[CH3:2][O:3][C:4](=[O:10])[C@@H:5]1[CH2:9][CH2:8][CH2:7][NH:6]1.C(N(CC)CC)C.[C:18](N1C=CN=C1)([N:20]1[CH:24]=[CH:23][N:22]=[CH:21]1)=[O:19].O>ClCCl>[CH3:2][O:3][C:4](=[O:10])[C@@H:5]1[CH2:9][CH2:8][CH2:7][N:6]1[C:18]([N:20]1[CH:24]=[CH:23][N:22]=[CH:21]1)=[O:19]

参加物

6

反応物 4

HCID 962WaterHCID 8471TriethylamineHCID 682631,1'-CarbonyldiimidazoleHCID 2733200methyl L-prolinate hydrochloride

生成物 1

HCID 675488891-(1H-Imidazol-1-ylcarbonyl)-L-proline methyl ester収率 100%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

L-proline methyl ester hydrochloride (0.300 g, 1.81 mmol) was dissolved in dichloromethane (5 ml). Triethylamine (0.202 g, 1.99 mmol) and 1,1′-carbonylbis-1H-imidazole (0.352 g, 2.17 mmol) were added, and the mixture was stirred at room temperature for five days. Water was added to the reaction solution, followed by extraction with dichloromethane. Then, the organic layer was washed with brine and dried over anhydrous sodium sulfate. Following concentration under reduced pressure, 0.404g of the title compound was obtained as a colorless oily substance (100%).

後処理

  1. extractionfollowed by extraction with dichloromethane
  2. washThen, the organic layer was washed with brine
  3. dry with materialdried over anhydrous sodium sulfate
  4. concentrationconcentration under reduced pressure

出典と根拠

ORDレコード
ord-86d9760c76fb49ea90d9def8ad4650fb
出典データセット
uspto-grants-2013_09
特許番号
US08536197B2

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