化工社化工社 化学情報印刷レポート · 研究参考用
Pinacolone → Methyl pivaloylacetate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Pinacolone | HCID 6416 | — |
| 反応物 | Dimethyl Carbonate | HCID 12021 | — |
| 反応物 | Sodium hydride | HCID 24758 | — |
| 溶媒 | Hexamethylphosphoramide | HCID 12679 | — |
| 生成物 | Methyl pivaloylacetate | HCID 99597 | 83.5% |
反応手順
60 g of sodium hydride were suspended in 450 cc of dimethyl carbonate and 100 cc of hexamethyl phosphoric acid triamide. 100 g of pinacolone (92%) were added slowly at 45° C and on completion of the addition, the reaction mixture was processed as described in 3 above. The yield was 83.5% of pivaloyl acetic acid methyl ester.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04031130 |
| 出典データセット | uspto-grants-1977_06 |
| ORD ID | ord-0fb85a1d813f4f5ea5765711fed7dda6 |
| 出典メモ | uspto-grants-1977_06 |