Butyl Isothiocyanate → 3-Butyl-1-[4-(2-formylhydrazino)phenyl]thiourea

HRID 437508

反応式

HRID 437508 の反応式
[CH:1]([NH:3][NH:4][C:5]1[CH:10]=[CH:9][C:8]([NH2:11])=[CH:7][CH:6]=1)=[O:2].[CH2:12]([N:16]=[C:17]=[S:18])[CH2:13][CH2:14][CH3:15]>C(O)C>[CH2:12]([NH:16][C:17](=[S:18])[NH:11][C:8]1[CH:9]=[CH:10][C:5]([NH:4][NH:3][CH:1]=[O:2])=[CH:6][CH:7]=1)[CH2:13][CH2:14][CH3:15]

参加物

4

反応物 2

HCID 11613Butyl IsothiocyanateHCID 113189Hydrazinecarboxaldehyde, 2-(4-aminophenyl)-

生成物 1

HCID 214278143-Butyl-1-[4-(2-formylhydrazino)phenyl]thiourea

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

1-Formyl-2-(4-aminophenyl)hydrazine (7.5 g, 0.05 mole) and butyl isothiocyanate (5.7 g, 0.05 mole) were mixed in ethanol (120 ml) and the mixture was refluxed for 30 minutes. The resulting solution was chilled in ice and upon scratching the product crystallized out as a white solid. The mixture was filtered and the solid was washed with ether. The product was dried to give a pale tan crystalline powder. Yield 9.8 g (74%), m.p. 129°-131° C.

後処理

  1. temperaturethe mixture was refluxed for 30 minutes
  2. temperatureThe resulting solution was chilled in ice
  3. customcrystallized out as a white solid
  4. filtrationThe mixture was filtered
  5. washthe solid was washed with ether
  6. customThe product was dried
  7. customto give a pale tan crystalline powder

出典と根拠

ORDレコード
ord-634785fa5bdd4c95b79e83f97e19bd12
出典データセット
uspto-grants-1977_06
特許番号
US04031127

関連ノート

読み込み中…