Malonic Acid → 1,3-Dipropylpyrimidine-2,4,6(1H,3H,5H)-trione
反応式
[CH2:1]([NH:4][C:5]([NH:7][CH2:8][CH2:9][CH3:10])=[O:6])[CH2:2][CH3:3].[C:11]([OH:17])(=O)[CH2:12][C:13]([OH:15])=O.C(OC(=O)C)(=O)C>C(O)(=O)C>[CH2:1]([N:4]1[C:11](=[O:17])[CH2:12][C:13](=[O:15])[N:7]([CH2:8][CH2:9][CH3:10])[C:5]1=[O:6])[CH2:2][CH3:3]参加物
5
実験手順
Synthesis was carried out according to the procedure of Goldner, Ann. Chem., 691, 142 (1966) using 1,3-di-n-propylurea (777 g., 5.38 mole), malonic acid (660 g., 6.34 mole), glacial acetic acid (1050 ml.) and acetic anhydride (2160 ml.) to obtain 790 g. (69.2%) of product, melting point 77° - 80° C. NMR and IR spectra were consistent with the assigned structure.
後処理
- customSynthesis
- customto obtain 790 g
出典と根拠
- ORDレコード
- ord-713a4702711a4589846a6d9a408246de
- 出典データセット
- uspto-grants-1977_06
- 特許番号
- US04031218
反応ノート
読み込み中…