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3-Indoleglyoxylyl chloride → 1-(Indol-3-ylglyoxyloyl)-4-(p-fluorophenoxy)piperidine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | 3-Indoleglyoxylyl chloride | HCID 89952 | — |
| 反応物 | 4-(4-Fluorophenoxy)piperidine | HCID 3734896 | — |
| 生成物 | 1-(Indol-3-ylglyoxyloyl)-4-(p-fluorophenoxy)piperidine | HCID 21428700 | — |
反応手順
By following the manipulative procedure described in Example 4(b), 4-(p-fluorophenoxy)piperidine is reacted with indole-3-glyoxyloyl chloride to give 1-(indol-3-ylglyoxyloyl)-4-(p-fluorophenoxy)piperidine as an off-white solid. The solid is recrystallized twice from a methanol and water mixture to give white needles of the glyoxamide, m.p. 205°-207° C.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04031221 |
| 出典データセット | uspto-grants-1977_06 |
| ORD ID | ord-6a6ad0c756cf4b878f2a1ef7fb2e16d2 |
| 出典メモ | uspto-grants-1977_06 |