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Phenyl chloroformate → 1-Phenoxycarbonyl-3-(p-fluorophenoxy)azetidine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Phenyl chloroformate | HCID 15891 | — |
| 反応物 | 1-Benzhydryl-3-(4-fluorophenoxy)azetidine | HCID 15053369 | — |
| 溶媒 | Toluene | HCID 1140 | — |
| 生成物 | 1-Phenoxycarbonyl-3-(p-fluorophenoxy)azetidine | HCID 21428738 | — |
反応手順
A solution of 20.0 g of 1-benzhydryl-3-(4-fluorophenoxy)azetidine and 10.3 g of phenylchloroformate in 200 ml. of toluene is refluxed for 16 hours. The reaction mixture is cooled, and the toluene is removed under reduced pressure to give a yellow oil. The oil is triturated with hexane to give a white solid of 1-phenoxycarbonyl-3-(p-fluorophenoxy)azetidine.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04031221 |
| 出典データセット | uspto-grants-1977_06 |
| ORD ID | ord-f1f12d4a48a34596b18ae613aeac5c68 |
| 出典メモ | uspto-grants-1977_06 |