Benzene → HCID 21428866、化合物

HRID 437624ノート

反応式

HRID 437624 の反応式
[Cl:1][C:2]1[CH:12]=[CH:11][C:5]([C:6]([N:8]2[CH2:10][CH2:9]2)=[O:7])=[CH:4][CH:3]=1.[C:13]1([N:19]2[C:23]3([CH2:28][CH2:27][NH:26][CH2:25][CH2:24]3)[C:22](=[O:29])[NH:21][CH2:20]2)[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1.C1C=CC=CC=1>CO>[Cl:1][C:2]1[CH:3]=[CH:4][C:5]([C:6]([NH:8][CH2:10][CH2:9][N:26]2[CH2:25][CH2:24][C:23]3([N:19]([C:13]4[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=4)[CH2:20][NH:21][C:22]3=[O:29])[CH2:28][CH2:27]2)=[O:7])=[CH:11][CH:12]=1

参加物

5

反応物 3

HCID 241BenzeneHCID 705561-Phenyl-1,3,8-triazaspiro(4.5)decan-4-oneHCID 2450271-(4-Chlorobenzoyl)aziridine

生成物 1

HCID 21428866HCID 21428866、化合物

試薬・触媒・溶媒 1

HCID 887Methanol溶媒

実験手順

A mixture of 1.82 parts of 1-(4-chlorobenzoyl)aziridine, 2.32 parts of 1-phenyl-1,3,8-triazaspiro[4,5]decan-4-one, 10.8 parts of benzene an 1.6 parts of methanol is stirred and refluxed for 1.50 hours. The reaction mixture is cooled and upon scratching, the product solidifies. It is filtered off, washed with benzene and crystallized from 2-propanol, yielding 1.53 parts of 4-chloro-N-[2-(4-oxo-1-phenyl-1,3,8-triazaspiro[4,5]dec-8-yl)ethyl]benzamide; mp. 200.6° C.

後処理

  1. temperaturerefluxed for 1.50 hours
  2. temperatureThe reaction mixture is cooled
  3. filtrationIt is filtered off
  4. washwashed with benzene
  5. customcrystallized from 2-propanol

出典と根拠

ORDレコード
ord-8f8b1ee3f79b4e99b20ada9df39c2347
出典データセット
uspto-grants-1977_06
特許番号
US04031226

反応ノート

読み込み中…