Water → 6-Bromo-1,2,3,9-tetrahydro-4H-carbazol-4-one

HRID 4377ノート

反応式

HRID 4377 の反応式
[Br:1][C:2]1[CH:7]=[CH:6][C:5]([NH:8]N=C2CCCC(=O)C2)=[CH:4][CH:3]=1.[OH2:17]>C(O)(=O)C.[Cl-].[Zn+2].[Cl-]>[Br:1][C:2]1[CH:3]=[C:4]2[C:5](=[CH:6][CH:7]=1)[NH:8][C:3]1[CH2:4][CH2:5][CH2:6][C:7](=[O:17])[C:2]2=1

参加物

5

反応物 2

HCID 962WaterHCID 566239871,3-Cyclohexanedione mono(4-bromophenylhydrazone)

生成物 1

HCID 201524426-Bromo-1,2,3,9-tetrahydro-4H-carbazol-4-one

試薬・触媒・溶媒 2

HCID 3007855Zincchloride触媒HCID 176Acetic Acid溶媒

実験手順

The product of Stage (i) (1.5 g) was heated under reflux with dry zinc chloride (16 g) in glacial acetic acid (75 ml) for 24 h. The mixture was cooled, poured into water (200 ml), and the resulting solid filtered off and dried (0.95 g). Purification by flash chromatography (E) gave the title compound as a solid (125 mg). T.l.c. (F), Rf 0.65

後処理

  1. temperatureThe mixture was cooled
  2. filtrationthe resulting solid filtered off
  3. customdried (0.95 g)
  4. customPurification by flash chromatography (E)

出典と根拠

ORDレコード
ord-477e144581644ea4bec3777f5ed06716
出典データセット
uspto-grants-1988_02
特許番号
US04725615

反応ノート

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