Hydrogen Peroxide → 5-Amino-3-isopropylisothiazole-4-carbonitrile

HRID 437710ノート

反応式

HRID 437710 の反応式
OO.[NH2:3][C:4]([CH:11]([CH3:13])[CH3:12])=[C:5]([C:9]#[N:10])[C:6](=[S:8])[NH2:7]>C(O)C>[NH2:7][C:6]1[S:8][N:3]=[C:4]([CH:11]([CH3:13])[CH3:12])[C:5]=1[C:9]#[N:10]

参加物

4

反応物 2

HCID 784Hydrogen PeroxideHCID 73793209HCID 73793209、化合物

生成物 1

HCID 152801535-Amino-3-isopropylisothiazole-4-carbonitrile収率 97%

試薬・触媒・溶媒 1

HCID 702Ethanol溶媒

実験手順

While maintaining the temperature below 50°, 86.1 g of 30% hydrogen peroxide was added dropwise to a solution of 128.3 g of 3-amino-2-cyano-4-methyl- 2-pentenethioamide in 600 ml of absolute ethanol. The mixture was stirred at room temperature for 19 hours, filtered and concentrated to about half volume. Water was added to cloud point and the solid allowed to separate. The solid was collected and dried to give 123.0 g of 5-amino-4-cyano-3-isopropylisothiazole, mp 133°-135°.

後処理

  1. filtrationfiltered
  2. concentrationconcentrated to about half volume
  3. additionWater was added to cloud point
  4. customto separate
  5. customThe solid was collected
  6. customdried

出典と根拠

ORDレコード
ord-c228324b2154465c96f2234733245f4b
出典データセット
uspto-grants-1977_06
特許番号
US04032322

反応ノート

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