Dimethylformamide → HCID 53748727、化合物

反応式

CS(Cl)(=O)=O.[NH2:6][C:7]1[S:11][N:10]=[C:9]([O:12][CH2:13][CH2:14][CH3:15])[C:8]=1[C:16]#[N:17].[CH3:18][N:19]([CH3:22])[CH:20]=O>>[C:16]([C:8]1[C:9]([O:12][CH2:13][CH2:14][CH3:15])=[N:10][S:11][C:7]=1[N:6]=[CH:18][N:19]([CH3:22])[CH3:20])#[N:17]

参加物

反応物 3

HCID 6228Dimethylformamide

HCID 31297Methanesulfonyl chloride

HCID 21396807HCID 21396807、化合物

生成物 1

HCID 53748727HCID 53748727、化合物

実験手順

A mixture of 13.7 g of methanesulfonyl chloride in 25 ml of dimethylformamide was stirred at room temperature for about 16 hours. Into the mixture was stirred 11 g of 5-amino-4-cyano-3-propoxyisothiazole which addition caused an exothermic reaction. The mixture was concentrated under reduced pressure and the residue was recrystallized from ethanol to give 2.7 g of crystalline N'-(4-cyano-3-propoxy-5-isothiazolyl)-N,N-dimethylformamidine, m.p. 117°-118°. The nmr spectrum was consistent with the assigned structure.