Phosgeniminium chloride → HCID 53949652、化合物

HRID 437716

反応式

HRID 437716 の反応式
[NH2:1][C:2]1[S:6][N:5]=[C:4]([CH2:7][CH2:8][CH3:9])[C:3]=1[C:10]#[N:11].[Cl-].[Cl:13][C:14](Cl)=[N+:15]([CH3:17])[CH3:16]>ClCCl>[C:10]([C:3]1[C:4]([CH2:7][CH2:8][CH3:9])=[N:5][S:6][C:2]=1[N:1]=[C:14]([Cl:13])[N:15]([CH3:17])[CH3:16])#[N:11]

参加物

4

反応物 2

HCID 2723945Phosgeniminium chlorideHCID 214267405-Amino-3-propyl-4-isothiazolecarbonitrile

生成物 1

HCID 53949652HCID 53949652、化合物収率 50.4%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

In the manner of Example VI, a solution of 8.4 g of 5-amino-4-cyano-3-propylisothiazole in 50 ml of dichloromethane was treated with 9.8 g of N-(dichloromethylene)-N,N-dimethylammonium chloride. After removal of the volatile materials under reduced pressure, the residue was recrystallized from 90:10 hexane:benzene to yield 6.5 g of N'-(4-cyano-3-propyl-5-isothiazolyl)-N,N-dimethylchloroformamidine, mp 108°-109°. The ir and nmr spectra were consistent with the assigned structure.

後処理

  1. customAfter removal of the volatile materials under reduced pressure
  2. customthe residue was recrystallized from 90:10 hexane

出典と根拠

ORDレコード
ord-d51fd68ff1724b3d9e11f4d4653d0b6d
出典データセット
uspto-grants-1977_06
特許番号
US04032322

関連ノート

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