Phosgeniminium chloride → HCID 54107383、化合物

HRID 437717

反応式

HRID 437717 の反応式
[NH2:1][C:2]1[S:6][N:5]=[C:4]([C:7]([CH3:10])([CH3:9])[CH3:8])[C:3]=1[C:11]#[N:12].[Cl-].[Cl:14][C:15](Cl)=[N+:16]([CH3:18])[CH3:17]>ClCCl>[C:7]([C:4]1[C:3]([C:11]#[N:12])=[C:2]([N:1]=[C:15]([Cl:14])[N:16]([CH3:18])[CH3:17])[S:6][N:5]=1)([CH3:9])([CH3:8])[CH3:10]

参加物

4

反応物 2

HCID 2723945Phosgeniminium chlorideHCID 214267415-Amino-3-(1,1-dimethylethyl)-4-isothiazolecarbonitrile

生成物 1

HCID 54107383HCID 54107383、化合物収率 67.7%

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

In the manner of Example VI, 9.1 g of 5-amino-3-tert-butyl- 4-cyanoisothiazole and 9.8 g of N-(dichloromethylene)-N,N-dimethylammonium chloride were allowed to react in 50 ml of dichloromethane. The volatile materials were evaporated under reduced pressure. The residue was recrystallized from hexane to give 9.2 g of N'-(3-tert-butyl-4 -cyano-5-isothiazolyl)-N,N-dimethylchloroformamidine, mp 94°-100°. The ir and nmr spectra were consistent with the assigned structures.

後処理

  1. customThe volatile materials were evaporated under reduced pressure
  2. customThe residue was recrystallized from hexane

出典と根拠

ORDレコード
ord-1504d35d190a4cb181d6e756db393ccc
出典データセット
uspto-grants-1977_06
特許番号
US04032322

関連ノート

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