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Phosgeniminium chloride → N'-(4-cyano-3-ethyl-5-isothiazolyl)-N,N-dimethylchloroformamidine
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Phosgeniminium chloride | HCID 2723945 | — |
| 反応物 | 5-Amino-4-cyano-3-ethylisothiazole | HCID 21426744 | — |
| 溶媒 | Dichloromethane | HCID 6344 | — |
| 生成物 | N'-(4-cyano-3-ethyl-5-isothiazolyl)-N,N-dimethylchloroformamidine | HCID 54431897 | 16.6% |
反応手順
In the manner of Example VI, 7.6 g of 5-amino-4 -cyano-3-ethylisothiazole and 8.1 g of N-(dichloromethylene) -N,N-dimethylammonium chloride were allowed to react in 100 ml of dichloromethane. The volatile materials were evaporated under reduced pressure. The residue was recrystallized twice from cyclohexane to give 2.0 g of N'-(4-cyano-3-ethyl-5-isothiazolyl)-N,N-dimethylchloroformamidine, mp 95°-97°. The nmr spectrum was consistent with the assigned structure.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US04032322 |
| 出典データセット | uspto-grants-1977_06 |
| ORD ID | ord-a72d35e7189c43719183e11077ed6902 |
| 出典メモ | uspto-grants-1977_06 |