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Diisopropylethylamine → Benzyl cis(+/-)-[3-methoxy-1-(6-methylpyrimidin-4-yl)piperidin-4-yl]carbamate
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Diisopropylethylamine | HCID 81531 | — |
| 反応物 | 4-Chloro-6-methylpyrimidine | HCID 581796 | — |
| 反応物 | Benzyl cis(+/-)-[3-methoxypiperidin-4-yl]carbamate hydrochloride | HCID 86648698 | — |
| 生成物 | Benzyl cis(+/-)-[3-methoxy-1-(6-methylpyrimidin-4-yl)piperidin-4-yl]carbamate | HCID 86648724 | — |
反応手順
The same operation as in Example (158a) was performed using benzyl cis(±)-[3-methoxypiperidin-4-yl]carbamate hydrochloride obtained in Example (160a) (549 mg, 1.83 mmol), 4-chloro-6-methylpyrimidine (235 mg, 1.83 mmol) and diisopropylethylamine (709 mg, 5.48 mmol), to obtain the title compound.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08536197B2 |
| 出典データセット | uspto-grants-2013_09 |
| ORD ID | ord-2b22532a8c924b11bd7247ef9245e68d |
| 出典メモ | uspto-grants-2013_09 |