Dimethyl Sulfoxide → 2-(4-Methyl-phenoxy)-5-methyl-phenylacetonitrile

HRID 437804ノート

反応式

HRID 437804 の反応式
Cl[CH2:2][C:3]1[CH:4]=[C:5]([CH3:17])[CH:6]=[CH:7][C:8]=1[O:9][C:10]1[CH:15]=[CH:14][C:13]([CH3:16])=[CH:12][CH:11]=1.CS(C)=O.[C-:22]#[N:23].[Na+]>O>[CH3:16][C:13]1[CH:14]=[CH:15][C:10]([O:9][C:8]2[CH:7]=[CH:6][C:5]([CH3:17])=[CH:4][C:3]=2[CH2:2][C:22]#[N:23])=[CH:11][CH:12]=1

参加物

5

反応物 3

HCID 679Dimethyl Sulfoxide2 回HCID 8929Sodium CyanideHCID 227679253-Chloromethyl-4-(4-methyl-phenoxy)-toluene

生成物 1

HCID 543008532-(4-Methyl-phenoxy)-5-methyl-phenylacetonitrile

試薬・触媒・溶媒 1

HCID 962Water溶媒

反応条件

温度
36 °C

実験手順

A solution of 108 g. of 3-chloromethyl-4-(4-methyl-phenoxy)-toluene in 70 ml. of dimethylsulfoxide is added dropwise at 20°-25° C. to a suspension of 23 g. of sodium cyanide in 35 ml. of dimethylsulfoxide. The mixture is subsequently stirred for 4 hours at 36° C., then diluted with 1 liter of water and extracted three times with benzene. The benzene extracts are washed three times with water, then dried over sodium sulfate and evaporated in vacuo, and there is obtained crude 2-(4-methyl-phenoxy)-5-methyl-phenylacetonitrile as a brown oil.

後処理

  1. extractionextracted three times with benzene
  2. washThe benzene extracts are washed three times with water
  3. dry with materialdried over sodium sulfate
  4. customevaporated in vacuo

出典と根拠

ORDレコード
ord-516555ed50fe41a19170c776b9a5d3d3
出典データセット
uspto-grants-1977_06
特許番号
US04032525

反応ノート

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