Methanol → 4-Chloro-2-(3-trifluoromethylphenoxy)-benzoic acid methyl ester

HRID 437828ノート

反応式

HRID 437828 の反応式
[Cl:1][C:2]1[CH:10]=[CH:9][C:5]([C:6]([OH:8])=[O:7])=[C:4]([O:11][C:12]2[CH:17]=[CH:16][CH:15]=[C:14]([C:18]([F:21])([F:20])[F:19])[CH:13]=2)[CH:3]=1.S(=O)(=O)(O)O.[CH3:27]O>>[CH3:27][O:7][C:6](=[O:8])[C:5]1[CH:9]=[CH:10][C:2]([Cl:1])=[CH:3][C:4]=1[O:11][C:12]1[CH:17]=[CH:16][CH:15]=[C:14]([C:18]([F:19])([F:20])[F:21])[CH:13]=1

参加物

4

反応物 3

HCID 887MethanolHCID 1118Sulfuric AcidHCID 227678684-Chloro-2-(3-trifluoromethyl-phenoxy)-benzoic acid

生成物 1

HCID 540086294-Chloro-2-(3-trifluoromethylphenoxy)-benzoic acid methyl ester

実験手順

136 G. of 4-chloro-2-(3-trifluoromethyl-phenoxy)-benzoic acid are boiled at reflux for 2.5 hours in a mixture of 1000 ml. of methanol and 100 ml. of concentrated sulfuric acid. After concentration of the mixture under vacuum, the residue is poured on to ice and extracted with benzene. The benzene extracts are washed with water, aqueous sodium bicarbonate solution and again with water. After evaporation of the benzene, there is obtained 4-chloro-2-(3-trifluoromethyl-phenoxy)-benzoic acid methyl ester in the form of an oil.

後処理

  1. temperatureat reflux for 2.5 hours in a mixture of 1000 ml
  2. additionAfter concentration of the mixture under vacuum, the residue is poured on to ice
  3. extractionextracted with benzene
  4. washThe benzene extracts are washed with water, aqueous sodium bicarbonate solution and again with water
  5. customAfter evaporation of the benzene

出典と根拠

ORDレコード
ord-3eb171084922475b8be2b3693a83eb9c
出典データセット
uspto-grants-1977_06
特許番号
US04032525

反応ノート

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