Methyl cis(+/-)-3-(4-{[(benzyloxy)carbonyl]amino}-3-methoxypiperidin-1-yl)-4-fluorobenzoate → HCID 86648746、化合物

HRID 43795ノート

反応式

HRID 43795 の反応式
C(OC([NH:11][C@H:12]1[CH2:17][CH2:16][N:15]([C:18]2[CH:19]=[C:20]([CH:25]=[CH:26][C:27]=2[F:28])[C:21]([O:23][CH3:24])=[O:22])[CH2:14][C@H:13]1[O:29][CH3:30])=O)C1C=CC=CC=1>[C].[Pd]>[NH2:11][C@H:12]1[CH2:17][CH2:16][N:15]([C:18]2[CH:19]=[C:20]([CH:25]=[CH:26][C:27]=2[F:28])[C:21]([O:23][CH3:24])=[O:22])[CH2:14][C@H:13]1[O:29][CH3:30]

参加物

3

反応物 1

HCID 86648744Methyl cis(+/-)-3-(4-{[(benzyloxy)carbonyl]amino}-3-methoxypiperidin-1-yl)-4-fluorobenzoate

生成物 1

HCID 86648746HCID 86648746、化合物収率 26.6%

試薬・触媒・溶媒 1

HCID 178418390HCID 178418390、化合物触媒

実験手順

The same operation as in Example (160c) was performed using methyl cis(±)-3-(4-{[(benzyloxy)carbonyl]amino}-3-methoxypiperidin-1-yl)-4-fluorobenzoate obtained in Example (181a) (101 mg, 0.24 mmol) and a 10% palladium-carbon catalyst (100 mg), to obtain 18 mg of the title compound as a colorless oily substance (26%). The resulting compound was used for the next reaction without purification.

出典と根拠

ORDレコード
ord-44e0541beb45485083542b8e7c3ddcb2
出典データセット
uspto-grants-2013_09
特許番号
US08536197B2

反応ノート

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