Water → 1,2,3,9-Tetrahydro-6-methoxy-9-methyl-4H-carbazol-4-one
反応式
[C:1](=O)([O-])[O-].[K+].[K+].[CH3:7][O:8][C:9]1[CH:10]=[C:11]2[C:19](=[CH:20][CH:21]=1)[NH:18][C:17]1[CH2:16][CH2:15][CH2:14][C:13](=[O:22])[C:12]2=1.S(OC)(OC)(=O)=O.O>CC(C)=O>[CH3:7][O:8][C:9]1[CH:10]=[C:11]2[C:19](=[CH:20][CH:21]=1)[N:18]([CH3:1])[C:17]1[CH2:16][CH2:15][CH2:14][C:13](=[O:22])[C:12]2=1参加物
6
実験手順
Anhydrous potassium carbonate (2.24 g) was added to a solution of the product of Stage (i) (3 g) in acetone (30 ml) at room temperature and stirred for 30 min. Dimethyl sulphate (1.6 ml) was added and the mixture was heated to reflux for 4 h. The resulting solution was poured into water (150 ml) and the resulting precipitate filtered off to give the title compound as a solid (2.5 g), m.p. 150°-151°.
後処理
- temperaturethe mixture was heated
- temperatureto reflux for 4 h
- filtrationthe resulting precipitate filtered off
出典と根拠
- ORDレコード
- ord-1ac4895b46ac455b903ac181d0e5e30d
- 出典データセット
- uspto-grants-1988_02
- 特許番号
- US04725615
反応ノート
読み込み中…