Water → 1,2,3,9-Tetrahydro-6-methoxy-9-methyl-4H-carbazol-4-one

HRID 4380

反応式

HRID 4380 の反応式
[C:1](=O)([O-])[O-].[K+].[K+].[CH3:7][O:8][C:9]1[CH:10]=[C:11]2[C:19](=[CH:20][CH:21]=1)[NH:18][C:17]1[CH2:16][CH2:15][CH2:14][C:13](=[O:22])[C:12]2=1.S(OC)(OC)(=O)=O.O>CC(C)=O>[CH3:7][O:8][C:9]1[CH:10]=[C:11]2[C:19](=[CH:20][CH:21]=1)[N:18]([CH3:1])[C:17]1[CH2:16][CH2:15][CH2:14][C:13](=[O:22])[C:12]2=1

参加物

6

反応物 4

HCID 962WaterHCID 6497Dimethyl SulfateHCID 11430Potassium CarbonateHCID 152128016-Methoxy-1,2,3,9-tetrahydro-4H-carbazol-4-one

生成物 1

HCID 197698301,2,3,9-Tetrahydro-6-methoxy-9-methyl-4H-carbazol-4-one収率 78.2%

試薬・触媒・溶媒 1

HCID 180Acetone溶媒

実験手順

Anhydrous potassium carbonate (2.24 g) was added to a solution of the product of Stage (i) (3 g) in acetone (30 ml) at room temperature and stirred for 30 min. Dimethyl sulphate (1.6 ml) was added and the mixture was heated to reflux for 4 h. The resulting solution was poured into water (150 ml) and the resulting precipitate filtered off to give the title compound as a solid (2.5 g), m.p. 150°-151°.

後処理

  1. temperaturethe mixture was heated
  2. temperatureto reflux for 4 h
  3. filtrationthe resulting precipitate filtered off

出典と根拠

ORDレコード
ord-1ac4895b46ac455b903ac181d0e5e30d
出典データセット
uspto-grants-1988_02
特許番号
US04725615

関連ノート

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