Phosphorus pentachloride → HCID 22465462、化合物

HRID 439289ノート

反応式

HRID 439289 の反応式
[CH2:1]([NH:3][C:4]1[S:5][C:6]([C:10]([OH:12])=O)=[C:7]([CH3:9])[N:8]=1)[CH3:2].C(NC1SC(C(Cl)=O)=C(C)N=1)C.P(Cl)(Cl)(Cl)(Cl)Cl.Cl.[NH2:32][CH:33]([C:36]1[S:37][CH:38]=[CH:39][CH:40]=1)[C:34]#[N:35]>C(N(CC)CC)C>[C:34]([CH:33]([NH:32][C:10]([C:6]1[S:5][C:4]([NH:3][CH2:1][CH3:2])=[N:8][C:7]=1[CH3:9])=[O:12])[C:36]1[S:37][CH:38]=[CH:39][CH:40]=1)#[N:35]

参加物

6

反応物 4

HCID 24819Phosphorus pentachlorideHCID 11327242-(Ethylamino)-4-methyl-1,3-thiazole-5-carboxylic acidHCID 133524562-Thiopheneacetonitrile, a-amino-, monohydrochlorideHCID 450818732-(Ethylamino)-4-methyl-1,3-thiazole-5-carbonyl chloride

生成物 1

HCID 22465462HCID 22465462、化合物収率 32%

試薬・触媒・溶媒 1

HCID 8471Triethylamine溶媒

実験手順

1.2g of 2-ethylamino-4-methyl-thiazole-5-carboxylic acid was converted into 2-ethylamino-4-methyl-thiazole-5-carboxylic acid chloride using 1.3g of phosphorus pentachloride according to the same procedure as EXAMPLE 1. Then 1.1g of amino-thiophen-2-yl-acetonitrile hydrochloride and 2.5ml of triethylamine were added thereto and the reaction mixture was treated according to the same procedure as EXAMPLE 1 to obtain 0.57g (Yield 32%) of the title compound.

後処理

  1. additionthe reaction mixture was treated

出典と根拠

ORDレコード
ord-b5450e7c900a4ec699651cc56c66b8ec
出典データセット
uspto-grants-1996_05
特許番号
US05514643

反応ノート

読み込み中…