Piperazine → 1-Undecylpiperazine
反応式
[NH:1]1[CH2:6][CH2:5][NH:4][CH2:3][CH2:2]1.Br[CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH3:18]>ClCCl>[CH2:18]([N:1]1[CH2:6][CH2:5][NH:4][CH2:3][CH2:2]1)[CH2:17][CH2:16][CH2:15][CH2:14][CH2:13][CH2:12][CH2:11][CH2:10][CH2:9][CH3:8]参加物
4
実験手順
Excess piperazine (5 eq) and 1-bromoundecane (1.0 eq) are dissolved in dichloromethane and allowed to react overnight. The mixture is extracted with aqueous sodium bicarbonate and the organic layer dried with sodium sulfate. The mixture is filtered, the solvent removed in vacuo and the residue purified by column chromatography.
後処理
- customto react overnight
- extractionThe mixture is extracted with aqueous sodium bicarbonate
- dry with materialthe organic layer dried with sodium sulfate
- filtrationThe mixture is filtered
- customthe solvent removed in vacuo
- customthe residue purified by column chromatography
出典と根拠
- ORDレコード
- ord-689265230eda49c3ab363bd8c0763242
- 出典データセット
- uspto-grants-1996_05
- 特許番号
- US05514651
反応ノート
読み込み中…