Piperazine → 1-Undecylpiperazine

HRID 439304

反応式

HRID 439304 の反応式
[NH:1]1[CH2:6][CH2:5][NH:4][CH2:3][CH2:2]1.Br[CH2:8][CH2:9][CH2:10][CH2:11][CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH3:18]>ClCCl>[CH2:18]([N:1]1[CH2:6][CH2:5][NH:4][CH2:3][CH2:2]1)[CH2:17][CH2:16][CH2:15][CH2:14][CH2:13][CH2:12][CH2:11][CH2:10][CH2:9][CH3:8]

参加物

4

反応物 2

HCID 4837PiperazineHCID 127441-Bromoundecane

生成物 1

HCID 129309111-Undecylpiperazine

試薬・触媒・溶媒 1

HCID 6344Dichloromethane溶媒

実験手順

Excess piperazine (5 eq) and 1-bromoundecane (1.0 eq) are dissolved in dichloromethane and allowed to react overnight. The mixture is extracted with aqueous sodium bicarbonate and the organic layer dried with sodium sulfate. The mixture is filtered, the solvent removed in vacuo and the residue purified by column chromatography.

後処理

  1. customto react overnight
  2. extractionThe mixture is extracted with aqueous sodium bicarbonate
  3. dry with materialthe organic layer dried with sodium sulfate
  4. filtrationThe mixture is filtered
  5. customthe solvent removed in vacuo
  6. customthe residue purified by column chromatography

出典と根拠

ORDレコード
ord-689265230eda49c3ab363bd8c0763242
出典データセット
uspto-grants-1996_05
特許番号
US05514651

関連ノート

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