Hydrochloric Acid → Benzoic acid, 2-amino-5-fluoro-3-nitro- (9CI)
反応式
C([NH:4][C:5]1[C:13]([N+:14]([O-:16])=[O:15])=[CH:12][C:11]([F:17])=[CH:10][C:6]=1[C:7]([OH:9])=[O:8])(=O)C.Cl>>[NH2:4][C:5]1[C:13]([N+:14]([O-:16])=[O:15])=[CH:12][C:11]([F:17])=[CH:10][C:6]=1[C:7]([OH:9])=[O:8]参加物
3
実験手順
2-Acetamido-5-fluoro-3-nitrobenzoic acid (200 mg, 0.83 mmol) was added to 3N hydrochloric acid (4.0 mL) and the solution allowed to reflux for 7 hours whereby the solution contained a bright yellow precipitate. The reaction was cooled to room temperature and the precipitate collected and dried to produce 2-amino-5-fluoro-3-nitrobenzoic acid (152 mg, 92%) as a yellow solid.
後処理
- temperatureto reflux for 7 hours whereby the solution
- customthe precipitate collected
- customdried
出典と根拠
- ORDレコード
- ord-acbae63fd07844028d84db8446c1d9e5
- 出典データセット
- uspto-grants-1996_05
- 特許番号
- US05514676
反応ノート
読み込み中…