5-Bromo-2-methoxybenzene-1-sulfonyl chloride → 5-Bromo-2-methoxy-N-(4-bromo-3-methyl-5-isoxazolyl)benzenesulfonamide

HRID 439382ノート

反応式

HRID 439382 の反応式
[NH2:1][C:2]1[O:6][N:5]=[C:4]([CH3:7])[C:3]=1[Br:8].[Br:9][C:10]1[CH:11]=[CH:12][C:13]([O:20][CH3:21])=[C:14]([S:16](Cl)(=[O:18])=[O:17])[CH:15]=1>>[Br:9][C:10]1[CH:11]=[CH:12][C:13]([O:20][CH3:21])=[C:14]([S:16]([NH:1][C:2]2[O:6][N:5]=[C:4]([CH3:7])[C:3]=2[Br:8])(=[O:17])=[O:18])[CH:15]=1

参加物

3

反応物 2

HCID 5200205-Bromo-2-methoxybenzene-1-sulfonyl chlorideHCID 104875194-Bromo-3-methylisoxazol-5-amine

生成物 1

HCID 186173335-Bromo-2-methoxy-N-(4-bromo-3-methyl-5-isoxazolyl)benzenesulfonamide収率 61%

実験手順

5-Bromo-2-methoxy-N-(4-bromo-3-methyl-5-isoxazolyl)benzenesulfonamide was prepared from 5-amino-4-bromo-3-methylisoxazole and 5-bromo-2-methoxybenzenesulfonyl chloride according to the procedures described in Example 5. The crude product was purified by recrystallization from ethyl acetate/hexanes to give a crystalline solid, m.p. 92°-195° C., yield 61%.

後処理

  1. customThe crude product was purified by recrystallization from ethyl acetate/hexanes
  2. customto give a crystalline solid, m.p. 92°-195° C., yield 61%

出典と根拠

ORDレコード
ord-336522347f294803992ac0284b8b5610
出典データセット
uspto-grants-1996_05
特許番号
US05514691

反応ノート

読み込み中…