化工社化工社 化学情報印刷レポート · 研究参考用
N-[4-Chloro-2-nitro-5-(trifluoromethyl)phenyl]acetamide → 4-Chloro-2-nitro-5-(trifluoromethyl)aniline
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | N-[4-Chloro-2-nitro-5-(trifluoromethyl)phenyl]acetamide | HCID 22318004 | — |
| 溶媒 | Hydrochloric Acid | HCID 313 | — |
| 生成物 | 4-Chloro-2-nitro-5-(trifluoromethyl)aniline | HCID 2737645 | — |
反応手順
A mixture of 3-acetamido-6-chloro-4-nitrobenzotrifluoride (780 mg, 2.76 mmol) in concentrated HCl (3 mL) was refluxed overnight and it was extracted by ethyl acetate (2×3 mL). The extract was dried over Mg2SO4 and evaporated to give 517 mg (78%) of 3-amino-6-chloro-4-nitrobenzofluoride. 1H NMR (CDCl3): δ6.205 (s, 2H); 7.206 (s, 1H); 8.263 (s, 1H).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US05514680 |
| 出典データセット | uspto-grants-1996_05 |
| ORD ID | ord-fe00b320c4814902abdb28b09a372c54 |
| 出典メモ | uspto-grants-1996_05 |